Finding That APOE4 Is Toxic in Alzheimer’s Can Help Guide Targeted Therapies

— Differing risk of APOE4 between ethnic backgrounds also may come into play

Source: Med Page Today
Publish Date: August 30, 2024
By Greg Laub
Interview With Jeffery Vance, MD, PhD

A working group of senior investigators, convened by the Alzheimer’s Disease Sequencing Project  (ADSP), has reached a consensus that the APOE4 gene, long debated in Alzheimer’s research, is definitively toxic. This breakthrough not only opens the door for targeted therapies but also underscores the gene’s varying risk levels across different populations.

In this exclusive MedPage Today video, Jeffery Vance, MD, PhD, of the University of Miami Miller School of Medicine, describes the findings from the data analysis and how they might significantly reshape the future of Alzheimer’s treatment strategies.

For the full video and transcript, please visit Med Page Today.